Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides.
Josephine Louise Robb, Frédérick Boisjoly, Arturo Israel Machuca-Parra, Adeline Coursan, Romane Manceau, Danie Majeur, Demetra Rodaros, Khalil Bouyakdan, Karine Greffard, Jean-François Bilodeau, Anik Forest, Caroline Daneault, Matthieu Ruiz, Cyril Laurent, Nathalie Arbour, Sophie Layé, Xavier Fioramonti, Charlotte Madore, Stephanie Fulton, Thierry Alquier
Brain, Behavior, and Immunity. 2025-01-01
10.1016/j.bbi.2024.09.027

A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion
Mireia Montaner, Jessica Denom, Vincent Simon, Wanqing Jiang, Marie K. Holt, Daniel I. Brierley, Claude Rouch, Ewout Foppen, Nadim Kassis, David Jarriault, Dawood Khan, Louise Eygret, Francois Mifsud, David J. Hodson, Johannes Broichhagen, Lukas Van Oudenhove, Xavier Fioramonti, Victor Gault, Daniela Cota, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne-Li, Stefan Trapp, Hirac Gurden, Christophe Magnan
Nat Commun. 2024-08-13
10.1038/s41467-024-51076-4

Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity
Stéphane Leon, Vincent Simon, Thomas H. Lee, Lukas Steuernagel, Samantha Clark, Nasim Biglari, Thierry Lesté-Lasserre, Nathalie Dupuy, Astrid Cannich, Luigi Bellocchio, Philippe Zizzari, Camille Allard, Delphine Gonzales, Yves Le Feuvre, Emeline Lhuillier, Alexandre Brochard, Jean Charles Nicolas, Jérémie Teillon, Macha Nikolski, Giovanni Marsicano, Xavier Fioramonti, Jens C. Brüning, Daniela Cota, Carmelo Quarta
Nat Commun. 2024-04-24
10.1038/s41467-024-47877-2

Serotonergic neurons are involved in the counter-regulatory response to hypoglycemia.
Hugo Martin, Adeline Coursan, Justine Lallement, Mathieu Di Miceli, Janany Kandiah, Ilyès Raho, Jasmine Buttler, Jean‐Philippe Guilloux, Philippe De Deurwaerdere, Sophie Layé, Vanessa H. Routh, Bruno P. Guiard, Christophe Magnan, Céline Cruciani‐Guglielmacci, Xavier Fioramonti
J Neuroendocrinology. 2023-10-19
10.1111/jne.13344

A New Role for Hypothalamic Glucose-Sensing Neurons in Hypoglycemia Unawareness
Xavier Fioramonti
Diabetes. 2023-07-20
10.2337/dbi22-0038

Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency
Julie Brossaud, Clémentine Bosch-Bouju, Nathalie Marissal-Arvy, Marie-Neige Campas-Lebecque, Jean-Christophe Helbling, Scott P. Webster, Brian R. Walker, Xavier Fioramonti, Guillaume Ferreira, Pascal Barat, Jean-Benoît Corcuff, Marie-Pierre Moisan
Diabetologia. 2023-06-10
10.1007/s00125-023-05942-3

Insulin modulates emotional behavior through a serotonin-dependent mechanism
Hugo Martin, Sébastien Bullich, Maud Martinat, Mathilde Chataigner, Mathieu Di Miceli, Vincent Simon, Samantha Clark, Jasmine Butler, Mareike Schell, Simran Chopra, Francis Chaouloff, Andre Kleinridders, Daniela Cota, Philippe De Deurwaerdere, Luc Pénicaud, Sophie Layé, Bruno P. Guiard, Xavier Fioramonti
Mol Psychiatry. 2022-10-07
10.1038/S41380-022-01812-3

Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe De Deurwaerdere, Antoine G. Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves De Koninck, Pascal Fossat
Sci. Adv.. 2022-07-29
10.1126/sciadv.abo0689

Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice
Mathieu Di Miceli, Maud Martinat, Moïra Rossitto, Agnès Aubert, Shoug Alashmali, Clémentine Bosch-Bouju, Xavier Fioramonti, Corinne Joffre, Richard P. Bazinet, Sophie Layé
IJMS. 2022-06-14
10.3390/ijms23126650

The menace of obesity to depression and anxiety prevalence
Stephanie Fulton, Léa Décarie-Spain, Xavier Fioramonti, Bruno Guiard, Shingo Nakajima
Trends in Endocrinology & Metabolism. 2022-01-01
10.1016/j.tem.2021.10.005

Functional heterogeneity of POMC neurons relies on mTORC1 signaling
Nicolas Saucisse, Wilfrid Mazier, Vincent Simon, Elke Binder, Caterina Catania, Luigi Bellocchio, Roman A. Romanov, Stéphane Léon, Isabelle Matias, Philippe Zizzari, Carmelo Quarta, Astrid Cannich, Kana Meece, Delphine Gonzales, Samantha Clark, Julia M. Becker, Giles S.H. Yeo, Xavier Fioramonti, Florian T. Merkle, Sharon L. Wardlaw, Tibor Harkany, Federico Massa, Giovanni Marsicano, Daniela Cota
Cell Reports. 2021-10-01
10.1016/j.celrep.2021.109800

The impact of insulin on the serotonergic system and consequences on diabetes‐associated mood disorders
Hugo Martin, Sébastien Bullich, Bruno P. Guiard, Xavier Fioramonti
J Neuroendocrinology. 2021-01-28
10.1111/jne.12928

Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output
Lin Lin, Adam H Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet
J. Lipid Res.. 2020-08-21
10.1194/jlr.ra120001024

In silico Hierarchical Clustering of Neuronal Populations in the Rat Ventral Tegmental Area Based on Extracellular Electrophysiological Properties
Mathieu Di Miceli, Zoé Husson, Philippe Ruel, Sophie Layé, Daniela Cota, Xavier Fioramonti, Clémentine Bosch-Bouju, Benjamin Gronier
Front. Neural Circuits. 2020-08-13
10.3389/fncir.2020.00051

Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.
Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, Suzanne van der Veldt, Marie-Lou Boyer, Frank Aby, Tarson Tolentino-Cortez, Jean-Christophe Helbling, Lucy Martine, Stéphane Grégoire, Stéphanie Cabaret, Sylvie Vancassel, Sophie Layé, Jing Xuan Kang, Xavier Fioramonti, Olivier Berdeaux, Gabriel Barreda-Gómez, Elodie Masson, Guillaume Ferreira, David W.L. Ma, Clementine Bosch-Bouju, Véronique De Smedt-Peyrusse, Pierre Trifilieff
Cell Metabolism. 2020-04-01
10.1016/j.cmet.2020.02.012

Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Chloé Berland, Enrica Montalban, Elodie Perrin, Mathieu Di Miceli, Yuko Nakamura, Maud Martinat, Mary Sullivan, Xue S. Davis, Mohammad Ali Shenasa, Claire Martin, Stefania Tolu, Fabio Marti, Stephanie Caille, Julien Castel, Sylvie Perez, Casper Gravesen Salinas, Chloé Morel, Jacob Hecksher-Sørensen, Martine Cador, Xavier Fioramonti, Matthias H. Tschöp, Sophie Layé, Laurent Venance, Philippe Faure, Thomas S. Hnasko, Dana M. Small, Giuseppe Gangarossa, Serge H. Luquet
Cell Metabolism. 2020-03-01
10.1016/j.cmet.2020.02.010

POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?
Carmelo Quarta, Xavier Fioramonti, Daniela Cota
Neuroscience. 2019-11-01
10.1016/j.neuroscience.2019.09.031

Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids
Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A. Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C. Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P. Guiard
J. Neurosci.. 2019-06-03
10.1523/jneurosci.2904-18.2019

The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system
Khalil Bouyakdan, Hugo Martin, Fabienne Liénard, Lionel Budry, Bouchra Taib, Demetra Rodaros, Chloé Chrétien, Éric Biron, Zoé Husson, Daniela Cota, Luc Pénicaud, Stephanie Fulton, Xavier Fioramonti, and Thierry Alquier
J Clin Invest. 2019-04-02
10.1172/JCI123454

Editorial: Brain Nutrient Sensing in the Control of Energy Balance: New Insights and Perspectives
Céline Cruciani-Guglielmacci, Xavier Fioramonti
Front. Physiol.. 2019-02-05
10.3389/fphys.2019.00051

Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing.
Lucie Desmoulins, Chloé Chrétien, Romain Paccoud, Stephan Collins, Céline Cruciani-Guglielmacci, Anne Galinier, Fabienne Liénard, Aurore Quinault, Sylvie Grall, Camille Allard, Claire Fenech, Lionel Carneiro, Thomas Mouillot, Audren Fournel, Claude Knauf, Christophe Magnan, Xavier Fioramonti, Luc Pénicaud, Corinne Leloup
Molecular Metabolism. 2019-02-01
10.1016/j.molmet.2018.11.007

Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection
Xavier Fioramonti, Chloé Chrétien, Corinne Leloup, Luc Pénicaud
Front. Physiol.. 2017-11-14
10.3389/fphys.2017.00875

Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice
Elise Laperrousaz, Valentine S. Moullé, Raphaël G. Denis, Nadim Kassis, Chloé Berland, Benoit Colsch, Xavier Fioramonti, Erwann Philippe, Amélie Lacombe, Charlotte Vanacker, Noémie Butin, Kimberley D. Bruce, Hong Wang, Yongping Wang, Yuanqing Gao, Cristina Garcia-Caceres, Vincent Prévot, Matthias H. Tschöp, Robert H. Eckel, Hervé Le Stunff, Serge Luquet, Christophe Magnan, Céline Cruciani-Guglielmacci
Diabetologia. 2017-04-29
10.1007/s00125-017-4282-7

Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis
Chloé Chrétien, Claire Fenech, Fabienne Liénard, Sylvie Grall, Charlène Chevalier, Sylvie Chaudy, Xavier Brenachot, Raymond Berges, Katie Louche, Romana Stark, Emmanuelle Nédélec, Amélie Laderrière, Zane B. Andrews, Alexandre Benani, Veit Flockerzi, Jean Gascuel, Jana Hartmann, Cédric Moro, Lutz Birnbaumer, Corinne Leloup, Luc Pénicaud, Xavier Fioramonti
Diabetes. 2016-11-29
10.2337/db16-1114

Hypothalamic sensing of ketone bodies after prolonged cerebral exposure leads to metabolic control dysregulation
Lionel Carneiro, Sarah Geller, Audrey Hébert, Cendrine Repond, Xavier Fioramonti, Corinne Leloup, Luc Pellerin
Sci Rep. 2016-10-06
10.1038/srep34909

Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice
Anne Drougard, Audren Fournel, Alysson Marlin, Etienne Meunier, Anne Abot, Tereza Bautzova, Thibaut Duparc, Katie Louche, Aurelie Batut, Alexandre Lucas, Sophie Le-Gonidec, Jean Lesage, Xavier Fioramonti, Cedric Moro, Philippe Valet, Patrice D. Cani, Claude Knauf
Sci Rep. 2016-08-23
10.1038/srep31849

Glucose and hypothalamic astrocytes: More than a fueling role?
C. Leloup, C. Allard, L. Carneiro, X. Fioramonti, S. Collins, L. Pénicaud
Neuroscience. 2016-05-01
10.1016/j.neuroscience.2015.06.007

Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth
Jonathan Breton, Naouel Tennoune, Nicolas Lucas, Marie Francois, Romain Legrand, Justine Jacquemot, Alexis Goichon, Charlène Guérin, Johann Peltier, Martine Pestel-Caron, Philippe Chan, David Vaudry, Jean-Claude do Rego, Fabienne Liénard, Luc Pénicaud, Xavier Fioramonti, Ivor S. Ebenezer, Tomas Hökfelt, Pierre Déchelotte, Sergueï O. Fetissov
Cell Metabolism. 2016-02-01
10.1016/j.cmet.2015.10.017

Evidence for hypothalamic ketone body sensing: impact on food intake and peripheral metabolic responses in mice
Lionel Carneiro, Sarah Geller, Xavier Fioramonti, Audrey Hébert, Cendrine Repond, Corinne Leloup, Luc Pellerin
American Journal of Physiology-Endocrinology and Metabolism. 2016-01-15
10.1152/ajpendo.00282.2015

Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice
Gaël Quesseveur, Benjamin Portal, Jean-Arnaud Basile, Pascal Ezan, Alexia Mathou, Hélène Halley, Corinne Leloup, Xavier Fioramonti, Nicole Déglon, Christian Giaume, Claire Rampon, Bruno P. Guiard
Front. Cell. Neurosci.. 2015-12-22
10.3389/fncel.2015.00490

Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice
Grace Fergusson, Mélanie Éthier, Mélanie Guévremont, Chloé Chrétien, Camille Attané, Erik Joly, Xavier Fioramonti, Marc Prentki, Vincent Poitout, Thierry Alquier
Molecular Metabolism. 2014-12-01
10.1016/j.molmet.2014.09.006

Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion.
Camille Allard, Lionel Carneiro, Sylvie Grall, Brandon H Cline, Xavier Fioramonti, Chloé Chrétien, Fawzia Baba-Aissa, Christian Giaume, Luc Pénicaud, Corinne Leloup
J Cereb Blood Flow Metab. 2013-12-04
10.1038/jcbfm.2013.206

Membrane potential dye imaging of ventromedial hypothalamus neurons from adult mice to study glucose sensing
Reema P. Vazirani, Xavier Fioramonti, Vanessa H. Routh
JoVE. 2013-11-27
10.3791/50861

Hypothalamic S-nitrosylation contributes to the counter-regulatory response impairment following recurrent hypoglycemia
Xavier Fioramonti, Adam Deak, Srinidhi Deshpande, Lionel Carneiro, Chunxue Zhou, Nazish Sayed, Branly Orban, Joshua R. Berlin, Luc Pénicaud, Corinne Leloup, Annie Beuve, Vanessa H. Routh
PLoS ONE. 2013-07-19
10.1371/journal.pone.0068709

Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model
Pierre-Antoine Crassous, Samba Couloubaly, Can Huang, Zongmin Zhou, Padmamalini Baskaran, David D. Kim, Andreas Papapetropoulos, Xavier Fioramonti, Walter N. Durán, Annie Beuve
American Journal of Physiology-Heart and Circulatory Physiology. 2012-09-01
10.1152/ajpheart.00138.2012

Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice
Alexandre Benani, Cécile Hryhorczuk, Alexandra Gouazé, Xavier Fioramonti, Xavier Brenachot, Christophe Guissard, Alice Krezymon, Thibaut Duparc, André Colom, Emmanuelle Nédélec, Caroline Rigault, Aleth Lemoine, Jean Gascuel, Rita Gerardy-Schahn, Philippe Valet, Claude Knauf, Anne Lorsignol, Luc Pénicaud
J. Neurosci.. 2012-08-29
10.1523/jneurosci.0624-12.2012

Importance of mitochondrial dynamin-related protein 1 in hypothalamic glucose sensitivity in rats.
Lionel Carneiro, Camille Allard, Christophe Guissard, Xavier Fioramonti, Cécile Tourrel-Cuzin, Danielle Bailbé, Corinne Barreau, Géraldine Offer, Emmanuelle Nédelec, Bénédicte Salin, Michel Rigoulet, Pascale Belenguer, Luc Pénicaud, Corinne Leloup
Antioxidants & Redox Signaling. 2012-08-01
10.1089/ars.2011.4254

NO resistance in angiotensin II–induced hypertension is associated with S-nitrosation of soluble guanylyl cyclase
Pierre-Antoine Crassous, Samba Couloubaly, Padma Baskaran, Zongmin Zhou, Andreas Papapetropoulos, David D Kim, Xavier Fioramonti, Walter N Durán, Annie Beuve
BMC Pharmacol. 2011-08-01
10.1186/1471-2210-11-S1-O33

Hypothalamic nitric oxide in hypoglycemia detection and counterregulation: a two-edged sword
Xavier Fioramonti, Zhentao Song, Reema P. Vazirani, Annie Beuve, Vanessa H. Routh
Antioxidants & Redox Signaling. 2011-02-01
10.1089/ars.2010.3331

Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation
Xavier Fioramonti, Nicolas Marsollier, Zhentao Song, Kurt A. Fakira, Reema M. Patel, Stacey Brown, Thibaut Duparc, Arnaldo Pica-Mendez, Nicole M. Sanders, Claude Knauf, Philippe Valet, Rory J. McCrimmon, Annie Beuve, Christophe Magnan, Vanessa H. Routh
Diabetes. 2009-11-23
10.2337/db09-0421

Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide
Nicolas Marsollier, Nadim Kassis, Karima Mezghenna, Maud Soty, Xavier Fioramonti, Amélie Lacombe, Aurélie Joly, Bruno Pillot, Carine Zitoun, José Vilar, Gilles Mithieux, René Gross, Anne-Dominique Lajoix, Vanessa Routh, Christophe Magnan, Céline Cruciani-Guglielmacci
PLoS ONE. 2009-08-14
10.1371/journal.pone.0006649

Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose
Beth Ann Murphy, Xavier Fioramonti, Nina Jochnowitz, Kurt Fakira, Karen Gagen, Sylvain Contie, Anne Lorsignol, Luc Penicaud, William J. Martin, Vanessa H. Routh
American Journal of Physiology-Cell Physiology. 2009-04-01
10.1152/ajpcell.00641.2008

Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance
Nazish Sayed, David D. Kim, Xavier Fioramonti, Toru Iwahashi, Walter N. Durán, Annie Beuve
Circulation Research. 2008-09-12
10.1161/CIRCRESAHA.108.175133

Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice
Stephanie Troy, Maud Soty, Lara Ribeiro, Laure Laval, Stéphanie Migrenne, Xavier Fioramonti, Bruno Pillot, Veronique Fauveau, Roberte Aubert, Benoit Viollet, Marc Foretz, Jocelyne Leclerc, Adeline Duchampt, Carine Zitoun, Bernard Thorens, Christophe Magnan, Gilles Mithieux, Fabrizio Andreelli
Cell Metabolism. 2008-09-01
10.1016/j.cmet.2008.08.008

Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice
Vanessa Tobin, Maude Le Gall, Xavier Fioramonti, Emilie Stolarczyk, Alba G. Blazquez, Christophe Klein, Magali Prigent, Patricia Serradas, Marie-Hélène Cuif, Christophe Magnan, Armelle Leturque, Edith Brot-Laroche
Diabetes. 2008-03-01
10.2337/db07-0928

Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?
Xavier Fioramonti, Sylvain Contié, Zhentao Song, Vanessa H. Routh, Anne Lorsignol, Luc Pénicaud
Diabetes. 2007-05-01
10.2337/db06-0567

Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation of food intake
Alexandre Benani, Stéphanie Troy, Maria Carmen Carmona, Xavier Fioramonti, Anne Lorsignol, Corinne Leloup, Louis Casteilla, Luc Pénicaud
Diabetes. 2007-01-01
10.2337/db06-0440

Brain glucose sensing: a subtle mechanism
Luc Pénicaud, Corinne Leloup, Xavier Fioramonti, Anne Lorsignol, Alexandre Benani
Current Opinion in Clinical Nutrition & Metabolic Care. 2006-07-01
10.1097/01.mco.0000232908.84483.e0

A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus
X. Fioramonti, A. Lorsignol, A. Taupignon, L. Penicaud
Diabetes. 2004-10-25
10.2337/diabetes.53.11.2767

Cerebral insulin increases brain response to glucose
T. Alquier, C. Leloup, N. Atef, X. Fioramonti, A. Lorsignol, L. Pénicaud
J Neuroendocrinology. 2003-01-01
10.1046/j.1365-2826.2003.00961.x