Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides.
Josephine Louise Robb, Frédérick Boisjoly, Arturo Israel Machuca-Parra, Adeline Coursan, Romane Manceau, Danie Majeur, Demetra Rodaros, Khalil Bouyakdan, Karine Greffard, Jean-François Bilodeau, Anik Forest, Caroline Daneault, Matthieu Ruiz, Cyril Laurent, Nathalie Arbour, Sophie Layé, Xavier Fioramonti, Charlotte Madore, Stephanie Fulton, Thierry Alquier
Brain, Behavior, and Immunity. 2025-01-01
10.1016/j.bbi.2024.09.027

Plant Extracts and ω-3 Improve Short-Term Memory and Modulate the Microbiota-Gut-Brain Axis in D-galactose Model Mice.
Marie Martin, Milan Boulaire, Céline Lucas, Adrien Peltier, Line Pourtau, David Gaudout, Sophie Layé, Véronique Pallet, Corinne Joffre, Anne-Laure Dinel
The Journal of Nutrition. 2024-12-01
10.1016/j.tjnut.2024.09.015

Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section.
Mathieu Di Miceli, Moïra Rossitto, Maud Martinat, Flore Marchaland, Sarah Kharbouche, Marion Graland, Farah Younes, Alexandra Séré, Agnès Aubert, Lydia Rabbaa Khabbaz, Charlotte Madore, Jean-Christophe Delpech, Rebeca Martín, Sophie Layé
Sci Rep. 2024-11-30
10.1038/s41598-024-80770-y

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Sophie Leclercq, Hany Ahmed, Camille Amadieu, Géraldine Petit, Ville Koistinen, Quentin Leyrolle, Marie Poncin, Peter Stärkel, Eloise Kok, Pekka J Karhunen, Philippe de Timary, Sophie Laye, Audrey M Neyrinck, Olli K Kärkkäinen, Kati Hanhineva, Nathalie Delzenne
eLife. 2024-11-29
10.7554/eLife.96937

Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation.
Marie Martin, Emie Debenay, Jeanne Bardinet, Adrien Peltier, Line Pourtau, David Gaudout, Sophie Layé, Véronique Pallet, Anne-Laure Dinel, Corinne Joffre
Inflamm. Res.. 2024-09-28
10.1007/s00011-024-01947-9

Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer's disease research.
Pasindu Hansana Singhaarachchi, Peter Antal, Frédéric Calon, Carsten Culmsee, Jean-Christophe Delpech, Martin Feldotto, Jorine Geertsema, Emmy E. Hoeksema, Aniko Korosi, Sophie Layé, Jonathan McQualter, Susanne R. de Rooij, Christoph Rummel, Mary Slayo, Luba Sominsky, Sarah J. Spencer
Neuroscience & Biobehavioral Reviews. 2024-07-01
10.1016/j.neubiorev.2024.105724

Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation.
Adam H. Metherel, Rodrigo Valenzuela, Brinley J. Klievik, Giulia Cisbani, Ruxandra D. Rotarescu, Melissa Gonzalez-Soto, Céline Cruciani-Guglielmacci, Sophie Layé, Christophe Magnan, David M. Mutch, Richard P. Bazinet
Journal of Lipid Research. 2024-04-01
10.1016/j.jlr.2024.100548

Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging
Camille Mougin, Mathilde Chataigner, Céline Lucas, Quentin Leyrolle, Véronique Pallet, Sophie Layé, Elodie Bouvret, Anne-Laure Dinel, Corinne Joffre
Foods. 2023-11-21
10.3390/foods12234199

How nutrients and natural products act on the brain: Beyond pharmacology.
Aurelie de Rus Jacquet, Sophie Layé, Frédéric Calon
Cell Reports Medicine. 2023-10-01
10.1016/j.xcrm.2023.101243

Bridging a mechanistic gap from diet to synapses
Deanna L. Benson, Sophie Layé
Proc. Natl. Acad. Sci. U.S.A.. 2023-08-02
10.1073/pnas.2309992120

Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
Valentine Turpin, Maud Schaffhauser, Mathieu Thabault, Agnès Aubert, Corinne Joffre, Eric Balado, Jean-Emmanuel Longueville, Maureen Francheteau, Christophe Burucoa, Maxime Pichon, Sophie Layé, Mohamed Jaber
Sci Rep. 2023-07-11
10.1038/s41598-023-38423-z

The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain.
Quentin Leyrolle, Lucia Prado-Perez, Sophie Layé
Front. Nutr.. 2023-06-09
10.3389/fnut.2023.1155533

Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice
Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Layé, Cristina Limatola, Marie-Ève Tremblay, Agnès Nadjar
Brain, Behavior, and Immunity. 2023-01-01
10.1016/j.bbi.2022.09.016

Insulin modulates emotional behavior through a serotonin-dependent mechanism
Hugo Martin, Sébastien Bullich, Maud Martinat, Mathilde Chataigner, Mathieu Di Miceli, Vincent Simon, Samantha Clark, Jasmine Butler, Mareike Schell, Simran Chopra, Francis Chaouloff, Andre Kleinridders, Daniela Cota, Philippe De Deurwaerdere, Luc Pénicaud, Sophie Layé, Bruno P. Guiard, Xavier Fioramonti
Mol Psychiatry. 2022-10-07
10.1038/S41380-022-01812-3

The EAT-Lancet reference diet and cognitive function across the life course.
Boushra Dalile, Curie Kim, Andy Challinor, Lucie Geurts, Eileen R Gibney, Marcelo V Galdos, Giorgio La Fata, Sophie Layé, John C Mathers, David Vauzour, J Martin Verkuyl, Sandrine Thuret
The Lancet Planetary Health. 2022-09-01
10.1016/s2542-5196(22)00123-1

Microbiota-derived metabolites as drivers of gut-brain communication.
Hany Ahmed, Quentin Leyrolle, Ville Koistinen, Olli Kärkkäinen, Sophie Layé, Nathalie Delzenne, Kati Hanhineva
Gut Microbes. 2022-07-28
10.1080/19490976.2022.2102878

Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice
Mathieu Di Miceli, Maud Martinat, Moïra Rossitto, Agnès Aubert, Shoug Alashmali, Clémentine Bosch-Bouju, Xavier Fioramonti, Corinne Joffre, Richard P. Bazinet, Sophie Layé
IJMS. 2022-06-14
10.3390/ijms23126650

N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar
Front. Cell. Neurosci.. 2022-02-10
10.3389/fncel.2022.802411

Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner
Alessia Costa, Barbara Rani, Thomaz F. S. Bastiaanssen, Francesco Bonfiglio, Eoin Gunnigle, Gustavo Provensi, Moira Rossitto, Marcus Böhme, Conall Strain, Clara S. Martínez, Patrizio Blandina, John F. Cryan, Sophie Layé, Renato Corradetti, Maria Beatrice Passani
IJMS. 2022-01-13
10.3390/ijms23020862

Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner.
Alessia Costa, Barbara Rani, Thomaz F. S. Bastiaanssen, Francesco Bonfiglio, Eoin Gunnigle, Gustavo Provensi, Moira Rossitto, Marcus Boehme, Conall Strain, Clara S. Martínez, Patrizio Blandina, John F. Cryan, Sophie Layé, Renato Corradetti, Maria Beatrice Passani
IJMS. 2022-01-13
10.3390/ijms23020862

Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Julia De Meij, Zain Alfanek, Lydie Morel, Fanny Decoeur, Quentin Leyrolle, Katherine Picard, Micael Carrier, Agnes Aubert, Alexandra Séré, Céline Lucas, Gerald Laforest, Jean-Christophe Helbling, Marie-Eve Tremblay, Daniela Cota, Marie-Pierre Moisan, Giovanni Marsicano, Sophie Layé, Agnès Nadjar
Cannabis and Cannabinoid Research. 2021-12-01
10.1089/can.2020.0170

Anthocyanin-rich bilberry extract exerts a complex nutrigenomic effect in hippocampus of ApoE-/- mice
Irena Krga, Anne-Laure Dinel, Sophie Laye, Nathalie Castanon, Dragan Milenkovic
Free Radical Biology and Medicine. 2021-12-01
10.1016/j.freeradbiomed.2021.08.117

Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging.
Mathilde Chataigner, Céline Lucas, Mathieu Di Miceli, Véronique Pallet, Sophie Laye, Alexis Mehaignerie, Elodie Bouvret, Anne-Laure Dinel, Corinne Joffre
Front. Nutr.. 2021-11-23
10.3389/fnut.2021.750292

Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice
Dragan Milenkovic, Irena Krga, Anne-Laure Dinel, Christine Morand, Sophie Laye, Nathalie Castanon
Journal of Functional Foods. 2021-10-01
10.1016/j.jff.2021.104609

N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony‐Lee Sterley, Clémentine Bosch‐Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie‐Kim St‐Pierre, Maude Bordeleau, Véronique De Smedt‐Peyrusse, Alexandran Séré, Leslie Schwendimann, Stephane Grégoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie‐Eve Tremblay, Sophie Layé, Agnes Nadjar
Glia. 2021-09-14
10.1002/glia.24088

Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders
Maud Martinat, Moïra Rossitto, Mathieu Di Miceli, Sophie Layé
Nutrients. 2021-04-02
10.3390/nu13041185

Fish Hydrolysate Supplementation Containing n-3 Long Chain Polyunsaturated Fatty Acids and Peptides Prevents LPS-Induced Neuroinflammation.
Mathilde Chataigner, Marie Martin, Céline Lucas, Veronique Pallet, Sophie Layé, Alexis Mehaignerie, Elodie Bouvret, Anne-Laure Dinel, Corinne Joffre
Nutrients. 2021-03-02
10.3390/nu13030824

Binge eating among young adults: association with sociodemographic factors, nutritional intake, dietary n-6:n-3 ratio and impulsivity.
Maryse Khoury, Santa Chamsine, Camil Merheb, Edouard Arfoul, Maria Rached, Farah Younes, Nada El Osta, Sophie Laye, Carla Aoun, Tatiana Papazian, Lydia Rabbaa Khabbaz
Br J Nutr. 2021-01-14
10.1017/s0007114521000118

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé
Nat Commun. 2020-11-30
10.1038/s41467-020-19861-z

Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations
Essi F. Biyong, Serge Alfos, Fabien Dumetz, Jean-Christophe Helbling, Agnès Aubert, Julie Brossaud, Aline Foury, Marie-Pierre Moisan, Sophie Layé, Emmanuel Richard, Elaine Patterson, Kiera Murphy, Kieran Rea, Catherine Stanton, Harriët Schellekens, John F. Cryan, Lucile Capuron, Véronique Pallet, Guillaume Ferreira
Int J Obes. 2020-11-22
10.1038/s41366-020-00723-z

Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice
M. Chataigner, P. Mortessagne, C. Lucas, V. Pallet, S. Layé, A. Mehaignerie, E. Bouvret, AL. Dinel, C. Joffre
Brain, Behavior, and Immunity. 2020-09-01
10.1016/j.bbi.2020.09.022

Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output
Lin Lin, Adam H Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet
J. Lipid Res.. 2020-08-21
10.1194/jlr.ra120001024

In silico Hierarchical Clustering of Neuronal Populations in the Rat Ventral Tegmental Area Based on Extracellular Electrophysiological Properties
Mathieu Di Miceli, Zoé Husson, Philippe Ruel, Sophie Layé, Daniela Cota, Xavier Fioramonti, Clémentine Bosch-Bouju, Benjamin Gronier
Front. Neural Circuits. 2020-08-13
10.3389/fncir.2020.00051

Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Grégoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Layé, A. Nadjar
Neuropsychopharmacol.. 2020-08-11
10.1038/s41386-020-00793-7

Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice
Anne-Laure Dinel, Céline Lucas, Damien Guillemet, Sophie Layé, Véronique Pallet, Corinne Joffre
Nutrients. 2020-06-15
10.3390/nu12061777

PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies
Mathieu Di Miceli, Clémentine Bosch-Bouju, Sophie Layé
Proc. Nutr. Soc.. 2020-04-17
10.1017/S0029665120000129

Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.
Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, Suzanne van der Veldt, Marie-Lou Boyer, Frank Aby, Tarson Tolentino-Cortez, Jean-Christophe Helbling, Lucy Martine, Stéphane Grégoire, Stéphanie Cabaret, Sylvie Vancassel, Sophie Layé, Jing Xuan Kang, Xavier Fioramonti, Olivier Berdeaux, Gabriel Barreda-Gómez, Elodie Masson, Guillaume Ferreira, David W.L. Ma, Clementine Bosch-Bouju, Véronique De Smedt-Peyrusse, Pierre Trifilieff
Cell Metabolism. 2020-04-01
10.1016/j.cmet.2020.02.012

Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Chloé Berland, Enrica Montalban, Elodie Perrin, Mathieu Di Miceli, Yuko Nakamura, Maud Martinat, Mary Sullivan, Xue S. Davis, Mohammad Ali Shenasa, Claire Martin, Stefania Tolu, Fabio Marti, Stephanie Caille, Julien Castel, Sylvie Perez, Casper Gravesen Salinas, Chloé Morel, Jacob Hecksher-Sørensen, Martine Cador, Xavier Fioramonti, Matthias H. Tschöp, Sophie Layé, Laurent Venance, Philippe Faure, Thomas S. Hnasko, Dana M. Small, Giuseppe Gangarossa, Serge H. Luquet
Cell Metabolism. 2020-03-01
10.1016/j.cmet.2020.02.010

n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging
Corinne Joffre, Anne-Laure Dinel, Mathilde Chataigner, Véronique Pallet, Sophie Layé
Nutrients. 2020-02-28
10.3390/nu12030647

Reward-related brain activity and behavior are associated with peripheral ghrelin levels in obesity
Volodymyr B. Bogdanov, Olena V. Bogdanova, Sandra Dexpert, Ines Delgado, Helen Beyer, Agnès Aubert, Bixente Dilharreguy, Cédric Beau, Damien Forestier, Patrick Ledaguenel, Eric Magne, Bruno Aouizerate, Sophie Layé, Guillaume Ferreira, Jennifer Felger, Giuseppe Pagnoni, Lucile Capuron
Psychoneuroendocrinology. 2020-02-01
10.1016/j.psyneuen.2019.104520

Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice
H. Fanet, F. Ducrocq, M. Tournissac, A. Oummadi, A. Lo, P. Bourrassa, V. De Smedt-Peyrusse, B. Azzougen, L. Capuron, S. Layé, F. Moussa, P. Trifilieff, F. Calon, S. Vancassel
Behavioural Brain Research. 2020-02-01
10.1016/j.bbr.2019.112348

Alzheimer's Disease and Helicobacter pylori Infection: Inflammation from Stomach to Brain?
Guillaume Albaret, Elodie Sifré, Pauline Floch, Sophie Laye, Agnès Aubert, Pierre Dubus, Lamia Azzi-Martin, Alban Giese, Nathalie Salles, Francis Mégraud, Christine Varon, Philippe Lehours, Claire Roubaud-Baudron
JAD. 2020-01-21
10.3233/jad-190496

Rapeseed oil fortified with micronutrients improves cognitive alterations associated with metabolic syndrome
Célia Fourrier, Camille Kropp, Agnès Aubert, Julie Sauvant, Carole Vaysse, Jean-Michel Chardigny, Sophie Layé, Corinne Joffre, Nathalie Castanon
Brain, Behavior, and Immunity. 2019-11-01
10.1016/j.bbi.2019.11.002

Reduction of acute mild stress corticosterone response and changes in stress‐responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract
Anne‐Laure Dinel, Isabelle Guinobert, Céline Lucas, Claude Blondeau, Valérie Bardot, Isabelle Ripoche, Lucile Berthomier, Véronique Pallet, Sophie Layé, Corinne Joffre
Food Sci Nutr. 2019-10-22
10.1002/fsn3.1249

N-3 Polyunsaturated Fatty Acids and the Resolution of Neuroinflammation

Front Pharmacol.. 2019-09-13
10.3389/fphar.2019.01022

Visualizing and Profiling Lipids in the OVLT of Fat-1 and Wild Type Mouse Brains during LPS-Induced Systemic Inflammation Using AP-SMALDI MSI
Janne Bredehöft, Dhaka Ram Bhandari, Fabian Johannes Pflieger, Sabine Schulz, Jing X. Kang, Sophie Layé, Joachim Roth, Rüdiger Gerstberger, Konstantin Mayer, Bernhard Spengler, Christoph Rummel
ACS Chem. Neurosci.. 2019-09-12
10.1021/acschemneuro.9b00435

Direct and indirect effects of lipids on microglia function
Q. Leyrolle, S. Layé, A. Nadjar
Neuroscience Letters. 2019-08-01
10.1016/j.neulet.2019.134348

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression
Richard P. Bazinet, Adam H. Metherel, Chuck T. Chen, Saame Raza Shaikh, Agnes Nadjar, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2019-07-01
10.1016/j.bbi.2019.07.001

Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids
Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A. Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C. Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P. Guiard
J. Neurosci.. 2019-06-03
10.1523/jneurosci.2904-18.2019

Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation
Marion Rincel, Maïwenn Olier, Amandine Minni, Camille Monchaux de Oliveira, Yann Matime, Eric Gaultier, Isabelle Grit, Jean-Christophe Helbling, Anna Maria Costa, Amandine Lépinay, Marie-Pierre Moisan, Sophie Layé, Laurent Ferrier, Patricia Parnet, Vassilia Theodorou, Muriel Darnaudéry
Psychopharmacology. 2019-05-01
10.1007/s00213-019-05252-w

Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
F. Decoeur, A. Benmamar-Badel, Q. Leyrolle, M. Persillet, S. Layé, A. Nadjar
Brain, Behavior, and Immunity. 2019-05-01
10.1016/j.bbi.2019.05.016

Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner
Rincel M, Aubert P, Chevalier J, Grohard PA, Basso L, Monchaux de Oliveira C, Helbling JC, Lévy É, Chevalier G, Leboyer M, Eberl G, Layé S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaudéry M.
Brain Behav Immun.. 2019-03-11
10.1016/j.bbi.2019.03.006

Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre
Brain, Behavior, and Immunity. 2019-02-01
10.1016/j.bbi.2018.07.025

Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity.
Célia Fourrier, Clémentine Bosch-Bouju, Raphaël Boursereau, Julie Sauvant, Agnès Aubert, Lucile Capuron, Guillaume Ferreira, Sophie Layé, Nathalie Castanon
Brain, Behavior, and Immunity. 2018-11-01
10.1016/j.bbi.2018.11.316

Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.
V.F. Labrousse, Q. Leyrolle, C. Amadieu, A. Aubert, A Sere, E. Coutureau, S. Grégoire, L. Bretillon, V. Pallet, P. Gressens, C. Joffre, A. Nadjar, S. Layé
Brain, Behavior, and Immunity. 2018-10-01
10.1016/j.bbi.2018.06.004

Food for mood: Relevance of nutritional omega-3 fatty acids for depression and anxiety
Thomas Larrieu, Sophie Layé
Front. Physiol.. 2018-08-06
10.3389/fphys.2018.01047

Impact of dietary fats on brain functions
Rosanna Chianese, Roberto Coccurello, Andrea Viggiano, Marika Scafuro, Marco Fiore, Giangennaro Coppola, Francesca Felicia Operto, Silvia Fasano, Sophie Laye, Riccardo Pierantoni, Rosaria Meccariello
CN. 2018-07-12
10.2174/1570159X15666171017102547

Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring
Charlotte Rey, Agnès Nadjar, Florent Joffre, Camille Amadieu, Agnès Aubert, Carole Vaysse, Véronique Pallet, Sophie Layé, Corinne Joffre
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-06-01
10.1016/j.plefa.2018.04.003

mTORC1 pathway disruption abrogates the effects of the ciliary neurotrophic factor on energy balance and hypothalamic neuroinflammation.
Caroline André, Caterina Catania, Julie Remus-Borel, Elodie Ladeveze, Thierry Leste-Lasserre, Wilfrid Mazier, Elke Binder, Delphine Gonzales, Samantha Clark, Omar Guzman-Quevedo, Djoher Nora Abrous, Sophie Layé, Daniela Cota
Brain, Behavior, and Immunity. 2018-05-01
10.1016/j.bbi.2018.03.014

Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions
Sophie Miquel, Claire Champ, Jon Day, Esther Aarts, Ben A. Bahr, Martijntje Bakker, Diána Bánáti, Vittorio Calabrese, Tommy Cederholm, John Cryan, Louise Dye, Jonathan A. Farrimond, Aniko Korosi, Sophie Layé, Stuart Maudsley, Dragan Milenkovic, M.Hasan Mohajeri, John Sijben, Alina Solomon, Jeremy P.E. Spencer, Sandrine Thuret, Wim Vanden Berghe, David Vauzour, Bruno Vellas, Keith Wesnes, Peter Willatts, Raphael Wittenberg, Lucie Geurts
Ageing Research Reviews. 2018-03-01
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Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice
Julien Bensalem, Stéphanie Dudonné, David Gaudout, Laure Servant, Frédéric Calon, Yves Desjardins, Sophie Layé, Pauline Lafenetre, Véronique Pallet
J Nutr Sci. 2018-01-01
10.1017/jns.2018.10

Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology
Sophie Layé, Agnès Nadjar, Corinne Joffre, Richard P. Bazinet
Pharmacol Rev. 2017-12-07
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Omega-3 polyunsaturated fatty acids and brain health: Preclinical evidence for the prevention of neurodegenerative diseases
Olivier Kerdiles, Sophie Layé, Frédéric Calon
Trends in Food Science & Technology. 2017-11-01
10.1016/j.tifs.2017.09.003

Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
A. Nadjar, Q. Leyrolle, C. Joffre, S. Laye
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01
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Gender specific behavioral alterations are associated with gut dysbiosis in mice exposed to multifactorial early-life adversity
M. Rincel, P. Aubert, J. Chevalier, P. Grohard, L. Basso, C. Monchaux, De Oliveira, E. Lévy, G. Chevalier, M. Leboyer, G. Eberl, N. Vergnolle, M. Neunlist, S. Layé, L. Capuron, H. Boudin, P. Lepage, M. Darnaudéry
European Neuropsychopharmacology. 2017-10-01
10.1016/s0924-977x(17)31269-5

Early restoration of gut barrier function abrogates the long-term neurobehavioral effects of early-life stress in rats
Marion Rincel, Amandine Minni, Maïwenn Olier, Camille Monchaux de Oliveira, Yann Matime, Julie Thomas, Eric Gauthier, Isabelle Grit, Anna-Maria Costa, Amandine Lépinay, Sophie Layé, Laurent Ferrier, Patricia Parnet, Vassilia Théodorou, Muriel Darnaudéry
Psychoneuroendocrinology. 2017-09-01
10.1016/j.psyneuen.2017.07.450

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro
Célia Fourrier, Julie Remus-Borel, Andrew D. Greenhalgh, Michel Guichardant, Nathalie Bernoud-Hubac, Michel Lagarde, Corinne Joffre, Sophie Layé
J Neuroinflammation. 2017-08-24
10.1186/s12974-017-0939-x

Amplification of mGlu5-Endocannabinoid Signaling Rescues Behavioral and Synaptic Deficits in a Mouse Model of Adolescent and Adult Dietary Polyunsaturated Fatty Acid Imbalance
Antonia Manduca, Anissa Bara, Thomas Larrieu, Olivier Lassalle, Corinne Joffre, Sophie Layé, Olivier J. Manzoni
J. Neurosci.. 2017-06-19
10.1523/JNEUROSCI.3516-16.2017

The effect of high-fat diet consumption on appetitive instrumental behavior in rats.
Frédéric Tantot, Shauna L. Parkes, Alain R. Marchand, Chloé Boitard, Fabien Naneix, Sophie Layé, Pierre Trifilieff, Etienne Coutureau, Guillaume Ferreira
Appetite. 2017-01-01
10.1016/j.appet.2016.10.001

Impact of perinatal exposure to high-fat diet and stress on responses to nutritional challenges, food-motivated behaviour and mesolimbic dopamine function.
M Romaní-Pérez, A L Lépinay, L Alonso, M Rincel, L Xia, H Fanet, S Caillé, M Cador, S Layé, S Vancassel, M Darnaudéry
Int J Obes. 2016-12-27
10.1038/ijo.2016.236

Impact of Lactobacillus fermentum and dairy lipids in the maternal diet on the fatty acid composition of pups' brain and peripheral tissues
C. Joffre, A.L. Dinel, A. Aubert, C. Fressange-Mazda, P. Le Ruyet, S. Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-12-01
10.1016/j.plefa.2016.10.002

Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.
Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye, Daniela Cota
Diabetes. 2016-11-30
10.2337/db16-0586

Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations
Chloé Boitard, Shauna L. Parkes, Amandine Cavaroc, Frédéric Tantot, Nathalie Castanon, Sophie Layé, Sophie Tronel, Gustavo Pacheco-Lopez, Etienne Coutureau, Guillaume Ferreira
Front. Behav. Neurosci.. 2016-11-21
10.3389/fnbeh.2016.00225

Modulation of brain PUFA content in different experimental models of mice
Corinne Joffre, Stéphane Grégoire, Véronique De Smedt, Niyazi Acar, Lionel Bretillon, Agnès Nadjar, Sophie Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-11-01
10.1016/j.plefa.2016.09.003

Maternal high-fat diet prevents developmental programming by early-life stress
M Rincel, A L Lépinay, P Delage, J Fioramonti, V S Théodorou, S Layé, M Darnaudéry
Transl Psychiatry. 2016-11-01
10.1038/tp.2016.235

Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood
A.L. Dinel, C. Rey, C. Baudry, C. Fressange-Mazda, P. Le Ruyet, A. Nadjar, P. Pallet, C. Joffre, S. Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-10-01
10.1016/j.plefa.2016.08.013

Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress
Clémentine Bosch-Bouju, Thomas Larrieu, Louisa Linders, Olivier J. Manzoni, Sophie Layé
Cell Reports. 2016-08-01
10.1016/j.celrep.2016.06.082

Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro
C. Rey, A. Nadjar, B. Buaud, C. Vaysse, A. Aubert, V. Pallet, S. Layé, C. Joffre
Brain, Behavior, and Immunity. 2016-07-01
10.1016/j.bbi.2015.12.013

Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases
Clémentine Bosch-Bouju, Sophie Layé
Cannabinoids in Health and Disease. 2016-06-15
10.5772/62498

Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice
A.L. Dinel, C. Rey, C. Bonhomme, P. Le Ruyet, C. Joffre, S. Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-06-01
10.1016/j.plefa.2016.03.013

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra
PLoS Biol. 2016-05-26
10.1371/journal.pbio.1002466

EPA/DHA and vitamin A supplementation improves spatial memory and alleviates the age-related decrease in hippocampal RXRγ and kinase expression in rats
Anne Létondor, Benjamin Buaud, Carole Vaysse, Emmanuel Richard, Sophie Layé, Véronique Pallet, Serge Alfos
Front. Aging Neurosci.. 2016-05-09
10.3389/fnagi.2016.00103

Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation
Aurore Thomazeau, Clémentine Bosch-Bouju, Olivier Manzoni, Sophie Layé
Cereb. Cortex. 2016-03-05
10.1093/cercor/bhw052

Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice
Julien Bensalem, Laure Servant, Serge Alfos, David Gaudout, Sophie Layé, Pauline Lafenetre, Véronique Pallet
Front. Behav. Neurosci.. 2016-02-09
10.3389/fnbeh.2016.00009

Examining techniques for measuring the effects of nutrients on mental performance and mood state
Mark Hamer, Louise Dye, E. Siobhan Mitchell, Sophie Layé, Caroline Saunders, Neil Boyle, Jeroen Schuermans, John Sijben
Eur J Nutr. 2016-01-07
10.1007/s00394-015-1143-3

How French subjects describe well-being from food and eating habits? Development, item reduction and scoring definition of the Well-Being related to Food Questionnaire (Well-BFQ©).
I. Guillemin, A. Marrel, B. Arnould, L. Capuron, A. Dupuy, E. Ginon, S. Layé, J.-M. Lecerf, M. Prost, M. Rogeaux, I. Urdapilleta, F.-A. Allaert
Appetite. 2016-01-01
10.1016/j.appet.2015.09.021

N-3 PUFAs and neuroinflammatory processes in cognitive disorders
Quentin Leyrolle, Sophie Layé, Agnès Nadjar
OCL. 2016-01-01
10.1051/ocl/2015064

Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota
Charlotte Madore, Quentin Leyrolle, Chloé Lacabanne, Anouk Benmamar-Badel, Corinne Joffre, Agnes Nadjar, Sophie Layé
Neural Plasticity. 2016-01-01
10.1155/2016/3597209

Nutritional Omega-3 deficiency alters glucocorticoid receptor-signaling pathway and neuronal morphology in regionally distinct brain structures associated with emotional deficits
Thomas Larrieu, Muna L. Hilal, Véronique De Smedt-Peyrusse, Nathalie Sans, Sophie Layé
Neural Plasticity. 2016-01-01
10.1155/2016/8574830

Role of n-3 PUFAs in inflammation via resolvin biosynthesis
Corinne Joffre, Charlotte Rey, Agnès Nadjar, Sophie Layé
OCL. 2015-12-18
10.1051/ocl/2015062

External Validity of the Well-Being Related to Food Questionnaire (Well-Bfq©): Variations According to the Subjects' Nutritional Status.
FA Allaert, E Ginon, M Rogeaux, I Urdapilleta, L Capuron, A Dupuy, S Layé, J Lecerf, M Prost, I Guillemin, A Marrel, B Arnould
Value in Health. 2015-11-01
10.1016/j.jval.2015.09.2679

Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?
David Vauzour, Anneloes Martinsen, Sophie Layé
Neurochemistry International. 2015-10-01
10.1016/j.neuint.2015.08.004

Microglia in neuronal plasticity: Influence of stress
Jean-Christophe Delpech, Charlotte Madore, Agnes Nadjar, Corinne Joffre, Eric S. Wohleb, Sophie Layé
Neuropharmacology. 2015-09-01
10.1016/j.neuropharm.2014.12.034

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity
Nathalie Castanon, Giamal Luheshi, Sophie Layé
Front. Neurosci.. 2015-07-03
10.3389/fnins.2015.00229

Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment
Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clementine Bosch-Bouju, Thomas Larrieu, Chloe Lacabanne, Julie Remus-Borel, Agnès Aubert, Corinne Joffre, Agnès Nadjar, Sophie Layé
Neuropsychopharmacol. 2015-05-07
10.1038/npp.2015.127

Omega 3, the necessary fatty acids for the brain,Les oméga 3, ces acides gras indispensables au cerveau
Sophie Layé
Cahiers de Nutrition et de Diététique. 2015-04-01
10.1016/j.cnd.2015.03.006

Tu1877 Targeted Epithelial Barrier Disruption Reveals IBS-Like Pathophysiology and Behavioral Modifications
Laurent Ferrier, Orsolya Inczefi, Amandine Lépinay, lin xia, Mathilde Leveque, Sophie Layé, Jerrold R. Turner, Muriel D. darnaudery, Vassilia Theodorou
Gastroenterology. 2015-04-01
10.1016/s0016-5085(15)33147-4

Obesity- and Neuroinflammation-Associated Mood and Cognitive Disorders
Nathalie Castanon, Giamal Luheshi, Sophie Layé
Neuroinflammation. 2015-03-06
10.1002/9781118732748.ch9

Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
J.-C. Delpech, N. Saucisse, S. L. Parkes, C. Lacabanne, A. Aubert, F. Casenave, E. Coutureau, N. Sans, S. Laye, G. Ferreira, A. Nadjar
Journal of Neuroscience. 2015-02-18
10.1523/jneurosci.3028-14.2015

Behavioral and transcriptomic fingerprints of an enriched environment in horses (Equus caballus)
Léa Lansade, Mathilde Valenchon, Aline Foury, Claire Neveux, Steve W. Cole, Sophie Layé, Bruno Cardinaud, Frédéric Lévy, Marie-Pierre Moisan
PLoS ONE. 2014-12-10
10.1371/journal.pone.0114384

Polyunsaturated fatty acids and their metabolites in brain function and disease
Richard P. Bazinet, Sophie Layé
Nat Rev Neurosci. 2014-11-12
10.1038/nrn3820

Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats
Anne Létondor, Benjamin Buaud, Carole Vaysse, Laurence Fonseca, Coralie Herrouin, Benjamin Servat, Sophie Layé, Véronique Pallet, Serge Alfos
Br J Nutr. 2014-10-21
10.1017/S0007114514002529

Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion.
T Larrieu, L M Hilal, C Fourrier, V De Smedt-Peyrusse, Sans N, L Capuron, S Layé
Transl Psychiatry. 2014-10-01
10.1038/tp.2014.108

Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes
Charlotte Madore, Agnès Nadjar, Jean-Christophe Delpech, A. Sere, A. Aubert, Céline Portal, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2014-10-01
10.1016/j.bbi.2014.03.021

Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood
Anne-Laure Dinel, Corinne Joffre, Pierre Trifilieff, Agnes Aubert, Aline Foury, Pascale Le Ruyet, Sophie Layé
J Neuroinflammation. 2014-09-17
10.1186/s12974-014-0155-x

Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion.
T Larrieu, L M Hilal, C Fourrier, V De Smedt-Peyrusse, Sans N, L Capuron, S Layé
Transl Psychiatry. 2014-09-01
10.1038/tp.2014.77

Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation
Jean-Christophe Delpech, Charlotte Madore, Corinne Joffre, Agnès Aubert, Jing Xuan Kang, Agnès Nadjar, Sophie Layé
Neuropsychopharmacol. 2014-08-05
10.1038/npp.2014.196

N-3 LCPUFA improves cognition: The young, the old and the sick
C. Joffre, A. Nadjar, M. Lebbadi, F. Calon, S. Laye
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2014-07-01
10.1016/j.plefa.2014.05.001

SFRP CO-10 - Milk fat in the perinatal period and inflammation,SFRP CO-10 – Lipides laitiers en période périnatale et inflammation
C. Joffre, A.L. Dinel, P. Le Ruyet, S. Laye
Archives de Pédiatrie. 2014-05-01
10.1016/S0929-693X(14)72248-1

Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging
Julie Sauvant, Jean-Christophe Delpech, Karine Palin, Nadia De Mota, Jennifer Dudit, Agnès Aubert, Hélène Orcel, Pascale Roux, Sophie Layé, Françoise Moos, Catherine Llorens-Cortes, Agnès Nadjar
PLoS ONE. 2014-02-05
10.1371/journal.pone.0087421

Adipose inflammation in obesity: relationship with circulating levels of inflammatory markers and association with surgery-induced weight loss.
Julie Lasselin, Eric Magne, Cédric Beau, Patrick Ledaguenel, Sandra Dexpert, Agnès Aubert, Sophie Layé, Lucile Capuron
The Journal of Clinical Endocrinology & Metabolism. 2014-01-01
10.1210/jc.2013-2673

N-3 polyunsaturated fatty acid and neuroinflammation in aging: Role in cognition
Sophie Layé, Charlotte Madore, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar
Pharma-Nutrition. 2014-01-01
10.1007/978-3-319-06151-1_6

The neuroimmune basis of fatigue.
Robert Dantzer, Cobi Johanna Heijnen, Annemieke Kavelaars, Sophie Laye, Lucile Capuron
Trends in Neurosciences. 2014-01-01
10.1016/j.tins.2013.10.003

Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide
C. Madore, C. Joffre, J.C. Delpech, V. De Smedt-Peyrusse, A. Aubert, L. Coste, S. Layé, A. Nadjar
Brain, Behavior, and Immunity. 2013-11-01
10.1016/j.bbi.2013.08.008

Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome
Nathalie Castanon, Sophie Layé
Metabolic Syndrome and Neurological Disorders. 2013-10-11
10.1002/9781118395318.ch32

Leucine supplementation protects from insulin resistance by regulating adiposity levels.
Elke Binder, Francisco J. Bermúdez-Silva, Caroline André, Melissa Elie, Silvana Y. Romero-Zerbo, Thierry Leste-Lasserre, llaria Belluomo, Adeline Duchampt, Samantha Clark, Agnes Aubert, Marco Mezzullo, Flaminia Fanelli, Uberto Pagotto, Sophie Layé, Gilles Mithieux, Daniela Cota
PLoS ONE. 2013-09-25
10.1371/journal.pone.0074705

Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response
Agnes Nadjar, Tamara Blutstein, Agnes Aubert, Sophie Laye, Philip G. Haydon
Glia. 2013-02-04
10.1002/glia.22465

What do you eat? Dietary omega 3 can help to slow the aging process
Sophie Layé
Brain, Behavior, and Immunity. 2013-02-01
10.1016/j.bbi.2012.11.002

Fatigue and cognitive symptoms in patients with diabetes: relationship with disease phenotype and insulin treatment.
Julie Lasselin, Sophie Layé, Jean-Baptiste Barreau, Alice Rivet, Marie-Josée Dulucq, Henri Gin, Lucile Capuron
Psychoneuroendocrinology. 2012-09-01
10.1016/j.psyneuen.2012.01.016

Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice
Aurélie Moranis, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Agnès Aubert, Philippe Guesnet, Monique Lavialle, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2012-07-01
10.1016/j.bbi.2011.11.001

Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice
Thomas Larrieu, Charlotte Madore, Corinne Joffre, Sophie Layé
J Physiol Biochem. 2012-06-16
10.1007/s13105-012-0179-6

Short-term long chain Omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice
Virginie F. Labrousse, Agnès Nadjar, Corinne Joffre, Laurence Costes, Agnès Aubert, Stéphane Grégoire, Lionel Bretillon, Sophie Layé
PLoS ONE. 2012-05-25
10.1371/journal.pone.0036861

Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice.
Chloe Boitard, Nicole Etchamendy, Julie Sauvant, Agnes Aubert, Sophie Tronel, Aline Marighetto, Sophie Layé, Guillaume Ferreira
Hippocampus. 2012-05-17
10.1002/hipo.22032

Neuroinflammation and aging: Influence of dietary n-3 polyunsaturated fatty acid
Sophie Layé, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Corinne Joffre, Thomas Larrieu, Charlotte Madore, Agnès Nadjar and Lucile Capuron
OCL. 2011-11-15
10.1684/ocl.2011.0412

Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms.
Lucile Capuron, Sebastian Schroecksnadel, Catherine Féart, Agnès Aubert, Denise Higueret, Pascale Barberger-Gateau, Sophie Layé, Dietmar Fuchs
Biological Psychiatry. 2011-07-01
10.1016/j.biopsych.2010.12.006

Neurobiology of inflammation-associated anorexia,Neurobiologie de l'anorexie inflammatoire
L. Gautron, S. Layé
Obes. 2011-04-20
10.1007/s11690-011-0278-5

Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
Mathieu Lafourcade, Thomas Larrieu, Susana Mato, Anais Duffaud, Marja Sepers, Isabelle Matias, Veronique De Smedt-Peyrusse, Virginie F Labrousse, Lionel Bretillon, Carlos Matute, Rafael Rodríguez-Puertas, Sophie Layé, Olivier J Manzoni
Nat Neurosci. 2011-01-30
10.1038/nn.2736

Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation.
L. Capuron, C. Poitou, D. Machaux-Tholliez, V. Frochot, J.-L. Bouillot, A. Basdevant, S. Layé, K. Clément
Psychol. Med.. 2010-10-20
10.1017/s0033291710001984

Polyunsaturated fatty acids, neuroinflammation and well being
Sophie Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 2010-04-01
10.1016/j.plefa.2010.02.006

Vitamin E status and quality of life in the elderly: influence of inflammatory processes.
Lucile Capuron, Aurélie Moranis, Nicole Combe, Florence Cousson-Gélie, Dietmar Fuchs, Véronique De Smedt-Peyrusse, Pascale Barberger-Gateau, Sophie Layé
Br J Nutr. 2009-06-01
10.1017/S0007114509990493

Age-related changes in nestin immunoreactivity in the rat pituitary gland
Laurent Gautron, Véronique De-Smedt, Sophie Layé
Neuroendocrinology. 2009-01-01
10.1159/000220994

Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice
Rozenn Mingam, Aurélie Moranis, Rose-Marie Bluthé, Véronique De Smedt-Peyrusse, Keith W. Kelley, Philippe Guesnet, Monique Lavialle, Robert Dantzer, Sophie Layé
European Journal of Neuroscience. 2008-11-01
10.1111/j.1460-9568.2008.06470.x

Study of Helicobacter pullorum proinflammatory Properties on human epithelial cells in vitro
C Varon, A Duriez, P Lehours, A Menard, S Laye, F Zerbib, F Megraud, D Laharie
Gut. 2008-06-25
10.1136/gut.2007.144501

Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization
Véronique De Smedt-Peyrusse, Françoise Sargueil, Aurélie Moranis, Hedi Harizi, Sébastien Mongrand, Sophie Layé
J Neurochem. 2008-04-01
10.1111/j.1471-4159.2007.05129.x

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain
Rozenn Mingam, Véronique De Smedt, Thierry Amédée, Rose-Marie Bluthé, Keith W. Kelley, Robert Dantzer, Sophie Layé
Brain, Behavior, and Immunity. 2008-02-01
10.1016/j.bbi.2007.08.007

Cytokines, sickness behavior, and depression
ROBERT DANTZER, ROSE-MARIE BLUTHÉ, NATHALIE CASTANON, KEITH W. KELLEY, JAN-PIETER KONSMAN, SOPHIE LAYE, JACQUES LESTAGE, PATRICIA PARNET
Psychoneuroimmunology. 2007-01-01
10.1016/B978-012088576-3/50019-8

Characterization of STAT3-expressing cells in the postnatal rat brain
Laurent Gautron, Véronique De Smedt-Peyrusse, Sophie Layé
Brain Research. 2006-07-01
10.1016/j.brainres.2006.04.115

Pituitary cocaine- and amphetamine-regulated transcript expression depends on the strain, sex and oestrous cycle in the rat
L. Kappeler, L. Gautron, S. Laye, R. Dantzer, P. Zizzari, J. Epelbaum, M. T. Bluet-Pajot
J Neuroendocrinol. 2006-06-01
10.1111/j.1365-2826.2006.01435.x

Influence of feeding status on neuronal activity in the hypothalamus during lipopolysaccharide-induced anorexia in rats
L. Gautron, R. Mingam, A. Moranis, C. Combe, S. Layé
Neuroscience. 2005-01-01
10.1016/j.neuroscience.2005.03.063

Nuclear factor κB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse
Agnès Nadjar, Chantal Combe, Sophie Layé, Viviane Tridon, Robert Dantzer, Thierry Amédée, Patricia Parnet
Journal of Neurochemistry. 2004-02-04
10.1046/j.1471-4159.2003.02097.x

Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus
Laurent Gautron, Michel Chaigniau, Sophie Layé
Brain Research. 2003-12-01
10.1016/j.brainres.2003.09.061

NFκB activation in mouse pituitary: Comparison of response to interleukin-1β and lipopolysaccharide
P. Parnet, F. Pousset, S. Laye
Journal of Neuroendocrinology. 2003-02-13
10.1046/j.1365-2826.2003.01013.x

In vivo activation of the interleukin-6 receptor/gp130 signaling pathway in pituitary corticotropes of lipopolysaccharide-treated rats
Laurent Gautron, Pierrette Lafon, Gérard Tramu, Sophie Layé
Neuroendocrinology. 2003-01-01
10.1159/000068336

Spatiotemporal analysis of signal transducer and activator of transcription 3 activation in rat brain astrocytes and pituitary following peripheral immune challenge
L Gautron, P Lafon, M Chaigniau, G Tramu, S Layé
Neuroscience. 2002-07-01
10.1016/S0306-4522(02)00115-X

Physiological significance of the interleukin 1 receptor accessory protein
Sophie Layé, Stéphane Liège, Kang-Sheng Li, Elisabeth Moze, Pierre J. Neveu
Neuroimmunomodulation. 2001-01-01
10.1159/000049030

Role of interleukin-1β and tumour necrosis factor-α in lipopolysaccharide-induced sickness behaviour: A study with interleukin-1 type I receptor-deficient mice
Rose-Marie Bluthe, Sophie Laye, Bruno Michaud, Chantal Combe, Robert Dantzer, Patricia Parnet
Eur J Neurosci. 2000-12-01
10.1046/j.1460-9568.2000.01348.x

Interleukin 1 receptor accessory protein (IL-1RAcP) is necessary for centrally mediated neuroendocrine and immune responses to IL-1β
Stéphane Liège, Sophie Layé, Kang-Sheng Li, Elisabeth Moze, Pierre J Neveu
Journal of Neuroimmunology. 2000-10-01
10.1016/S0165-5728(00)00331-3

Human/mouse interleukin-1 receptor/receptor accessory protein interactions in IL-1β-induced NFκB activation
Sophie Layé, Johan Lundkvist, Tamas Bartfai
FEBS Letters. 1998-06-16
10.1016/S0014-5793(98)00537-7

Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor
David Malinowsky, Johan Lundkvist, Sophie Layé, Tamas Bartfai
FEBS Letters. 1998-06-16
10.1016/S0014-5793(98)00467-0

Cytokines and sickness behavior
ROBERT DANTZER, ROSE-MARIE BLUTHÉ, SOPHIE LAYÉ, JEAN-LUC BRET-DIBAT, PATRICIA PARNET, KEITH W. KELLEY
Annals of the New York Academy of Sciences. 1998-05-01
10.1111/j.1749-6632.1998.tb09597.x

Blockade of brain type II interleukin-1 receptors potentiates IL1β-induced anorexia in mice
Sandrine Cremona, Sophie Layé, Robert Dantzer, Patricia Parnet
Neuroscience Letters. 1998-04-01
10.1016/S0304-3940(98)00238-9

Regulation of cytokine gene expression in the central nervous system by glucocorticoids: Mechanisms and functional consequences
E.Goujon, S.Layé, P.Parnet, R.Dantzer
Psychoneuroendocrinology. 1997-01-01
10.1016/S0306-4530(97)00009-7

Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1β converting enzyme in the pituitary and brain of mice
S Layé, E Goujon, C Combe, R VanHoy, K.W Kelley, P Parnet, R Dantzer
Journal of Neuroimmunology. 1996-08-01
10.1016/0165-5728(96)00066-5

Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide
Emmanuelle Goujon, Patricia Parnet, Sophie Layé, Chantal Combe, Robert Dantzer
Molecular Brain Research. 1996-02-01
10.1016/0169-328X(95)00242-K

Stress downregulates lipopolysaccharide-induced expression of proinflammatory cytokines in the spleen, pituitary, and brain of mice
E. Goujon, P. Parnet, S. Laye, C. Combe, K.W. Kelley, R. Dantzer
Brain, Behavior, and Immunity. 1995-12-01
10.1006/brbi.1995.1028

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice
Sophie Layé, Patricia Parnet, Emmanuelle Goujon, Robert Dantzer
Molecular Brain Research. 1994-11-01
10.1016/0169-328X(94)90197-X